abstract：:Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the "epidemic" of immune-mediated d...

journal_title：Clinical reviews in allergy & immunology

authors： Weinstock JV

更新日期：2015-10-01 00:00:00

abstract：:Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoi...

journal_title：Clinical reviews in allergy & immunology

authors： Judson MA

更新日期：2015-08-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterized histologically by the presence of chronic non-suppurative destructive cholangitis of the small interlobular bile duct, leading to chronic progressive cholestasis. Most PBC patients are asymptomatic and have a reasonable prognosis, but a few develop esophageal varices or...

journal_title：Clinical reviews in allergy & immunology

authors： Katsumi T,Tomita K,Leung PS,Yang GX,Gershwin ME,Ueno Y

更新日期：2015-06-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration. Patients with a biochemical response to UDCA therapy have a similar survival rate compared to the general population. However, up to 40% of P...

journal_title：Clinical reviews in allergy & immunology

authors： Floreani A,Franceschet I,Perini L,Cazzagon N,Gershwin ME,Bowlus CL

更新日期：2015-06-01 00:00:00

abstract：:One of the important factors and consequences in persistent asthma is the change in the vasculature of the airways and lung parenchyma. These changes could contribute to worsening asthma control and predispose asthmatics to critical asthma syndromes. For many years, the contribution of vasculature to severe asthma was...

journal_title：Clinical reviews in allergy & immunology

authors： Avdalovic M

更新日期：2015-02-01 00:00:00

abstract：:Patients presenting to the emergency department (ED) or clinic with acute exacerbation of asthma (AEA) can be very challenging varying in both severity and response to therapy. High-dose, frequent or continuous nebulized short-acting beta2 agonist (SABA) therapy that can be combined with a short-acting muscarinic anta...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Sutter ME,Chan AL

更新日期：2015-02-01 00:00:00

abstract：:The critical asthma syndrome (CAS) encompasses the most severe, persistent, refractory asthma patients for the clinician to manage. Personalized pharmacotherapy is necessary to prevent the next acute severe asthma exacerbation, not just the control of symptoms. The 2007 National Asthma Education and Prevention Program...

journal_title：Clinical reviews in allergy & immunology

authors： Albertson TE,Schivo M,Gidwani N,Kenyon NJ,Sutter ME,Chan AL,Louie S

更新日期：2015-02-01 00:00:00

abstract：:Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia ...

journal_title：Clinical reviews in allergy & immunology

authors： Damoiseaux J,Cohen Tervaert JW

更新日期：2014-12-01 00:00:00

abstract：:Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenan...

journal_title：Clinical reviews in allergy & immunology

authors： Liu Y,Yin H,Zhao M,Lu Q

更新日期：2014-10-01 00:00:00

abstract：:This review includes a variety of extremely rare and unusual hymenoptera sting (HS) circumstances with regard to sting localization, geographic region, massivity of multiple stings, and particularly related to clinical symptoms. Such reactions occur in a temporal relationship to HS (s), differ from typical allergic sy...

journal_title：Clinical reviews in allergy & immunology

authors： Mingomataj EÇ,Bakiri AH,Ibranji A,Sturm GJ

更新日期：2014-08-01 00:00:00

abstract：:The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, whi...

journal_title：Clinical reviews in allergy & immunology

authors： Qamar N,Fuleihan RL

更新日期：2014-04-01 00:00:00

abstract：:Illicit stimulants, such as cocaine, amphetamine, and their derivatives (e.g., "ecstasy"), continue to exact heavy toll on health care in both developed and developing countries. The US Department of Health and Human Service reported over one million illicit drug-related emergency department visits in 2010, which was ...

journal_title：Clinical reviews in allergy & immunology

authors： Tseng W,Sutter ME,Albertson TE

更新日期：2014-02-01 00:00:00

abstract：:The incidence of autoimmune diseases is increasing in Western countries, possibly due to the improved sanitary conditions and reduced exposure to infections in childhood (the hygiene hypothesis). There is an ongoing debate whether infection prevents or precipitates autoimmune diseases. Various helminths species used i...

journal_title：Clinical reviews in allergy & immunology

authors： Ben-Ami Shor D,Harel M,Eliakim R,Shoenfeld Y

更新日期：2013-10-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histological...

journal_title：Clinical reviews in allergy & immunology

authors： Tsuneyama K,Baba H,Kikuchi K,Nishida T,Nomoto K,Hayashi S,Miwa S,Nakajima T,Nakanishi Y,Masuda S,Terada M,Imura J,Selmi C

更新日期：2013-08-01 00:00:00

abstract：:Legumes belonging to Fabaceae family of the order Fabales are a rich and important source of proteins and many essential elements. Due to its nutritious elements, these are preferably included in human diet in most part of the world. But, unfortunately, IgE binding proteins have been identified in majority of legumes,...

journal_title：Clinical reviews in allergy & immunology

authors： Verma AK,Kumar S,Das M,Dwivedi PD

更新日期：2013-08-01 00:00:00

abstract：:Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD ch...

journal_title：Clinical reviews in allergy & immunology

authors： Lerner A,Shapira Y,Agmon-Levin N,Pacht A,Ben-Ami Shor D,López HM,Sanchez-Castanon M,Shoenfeld Y

更新日期：2012-06-01 00:00:00

abstract：:Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal...

journal_title：Clinical reviews in allergy & immunology

authors： Aronovich R,Katzav A,Chapman J

更新日期：2012-04-01 00:00:00

abstract：:Mixed cryoglobulinemia (MC) syndrome is an immune complex-mediated vasculitis characterized by the clinical triad of purpura, weakness, and arthralgias, the morbidity of which is mainly related to kidney and peripheral nervous system dysfunction as well as to the development of a secondary lymphoma (Ferri et al. Autoi...

journal_title：Clinical reviews in allergy & immunology

authors： Lidar M,Lipschitz N,Agmon-Levin N,Langevitz P,Barzilai O,Ram M,Porat-Katz BS,Bizzaro N,Damoiseaux J,Tervaert JW,deVita S,Bombardieri S,Shoenfeld Y

更新日期：2012-04-01 00:00:00

abstract：:Patients with primary immunodeficiencies are prone to develop enteropathy of unknown pathogenesis. We hypothesize that ineffective clearance of gastrointestinal pathogens, particularly viruses, in combination with defective immune regulation may cause inflammatory enteropathy in certain immunodeficient hosts. We revie...

journal_title：Clinical reviews in allergy & immunology

authors： van de Ven AA,Hoytema van Konijnenburg DP,Wensing AM,van Montfrans JM

更新日期：2012-02-01 00:00:00

abstract：:It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processing enzymes. Survival of motor neuron 1 (SMN1) is well-known as a causative gene for spinal muscular atrophy (SMA) and mutations of glycyl- and tyrosyl-tRNA synthetases are identified as a cause of distal SMA and Charcot-...

journal_title：Clinical reviews in allergy & immunology

authors： Satoh M,Ceribelli A,Chan EK

更新日期：2012-02-01 00:00:00

abstract：:Therapy of atopic dermatitis should comprise emollients, topical glucocorticosteroids, or calcineurin inhibitors, phototherapies, immunosuppressants like cyclosporin A, and other treatments. All these treatments should be improved, thanks to research. But new therapeutic perspectives should be given by topical anti-in...

journal_title：Clinical reviews in allergy & immunology

authors： Misery L

更新日期：2011-12-01 00:00:00

abstract：:The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antipho...

journal_title：Clinical reviews in allergy & immunology

authors： Cervera R,Balasch J

更新日期：2010-12-01 00:00:00

abstract：:Prognosis of several autoimmune diseases, especially rheumatoid arthritis (RA), ankylosing spondylitis, Crohn's disease (CD), and psoriasis, usually refractory to conventional treatment improved considerably with the introduction of tumor necrosis factor alpha (TNF-alpha) antagonistic agents, which is now available (i...

journal_title：Clinical reviews in allergy & immunology

authors： Emi Aikawa N,de Carvalho JF,Artur Almeida Silva C,Bonfá E

更新日期：2010-04-01 00:00:00

abstract：:The term "mold" is utilized to define the ubiquitous fungal species commonly found in household dust and observed as visible multicellular filaments. Several well-defined human diseases are known to be caused or exacerbated by mold or by exposure to their byproducts. Among these, a solid connection has been establishe...

journal_title：Clinical reviews in allergy & immunology

authors： Pettigrew HD,Selmi CF,Teuber SS,Gershwin ME

更新日期：2010-04-01 00:00:00

abstract：:The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, t...

journal_title：Clinical reviews in allergy & immunology

authors： Matthias T,Pfeiffer S,Selmi C,Eric Gershwin M

更新日期：2010-04-01 00:00:00

abstract：:Every 2 years, an International Congress of Autoimmunity is organized and held with the intent of creating a new base for continuing interdisciplinary and international research, including further opportunities to train in the field of autoimmunity. In September 2008, the Congress of Autoimmunity was held in Porto, Po...

journal_title：Clinical reviews in allergy & immunology

authors： Matthias T,Shoenfeld Y

更新日期：2010-04-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a use...

journal_title：Clinical reviews in allergy & immunology

authors： de Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2010-04-01 00:00:00

abstract：:Through the last decade, clinical immunology has witnessed a considerable progress in understanding the role of the innate immunity in human host defense, with Toll-like receptors (TLRs) being the most extensively innate immune receptors investigated. Growing literature documents the relevance of TLR signaling pathway...

journal_title：Clinical reviews in allergy & immunology

authors： Suhir H,Etzioni A

更新日期：2010-02-01 00:00:00

abstract：:Pulmonary function testing is useful for the diagnosis and management of a variety of pulmonary conditions, and the most commonly obtained component is spirometry. Spirometry is most useful in the evaluation of obstructive airway disorders but can be a helpful tool in the management of patients with chest restriction ...

journal_title：Clinical reviews in allergy & immunology

authors： Liou TG,Kanner RE

更新日期：2009-12-01 00:00:00

abstract：:Inhibitors to factor VIII (FVIII) are alloantibodies directed against epitopes able to neutralise FVIII procoagulant activity. They may render FVIII replacement therapy ineffective. They represent the most severe complication of haemophilia A. At least three mechanisms of FVIII neutralisation activity by anti-FVIII an...

journal_title：Clinical reviews in allergy & immunology

authors： Tellier Z,André MH,Polack B

更新日期：2009-10-01 00:00:00

abstract：:Atherosclerosis is a disease of the vascular wall, which predominantly affects large and medium-sized arteries. It represents a leading cause of morbidity and mortality in the Western world. In the last few decades, it has been clearly shown that immune system plays a relevant role in atherogenesis. The effectors of b...

journal_title：Clinical reviews in allergy & immunology

authors： Bassi N,Zampieri S,Ghirardello A,Tonon M,Zen M,Cozzi F,Doria A

更新日期：2009-08-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disease of the liver and bile ducts that is associated with inflammatory bowel disease, generally leads to end-stage liver disease, and is complicated by malignancies of the biliary tree and the large intestine. The pathogenesis of PSC remains enigmati...

journal_title：Clinical reviews in allergy & immunology

authors： Beuers U,Kullak-Ublick GA,Pusl T,Rauws ER,Rust C

更新日期：2009-02-01 00:00:00

abstract：:Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results in abnormal viscous mucoid secretions in multiple organs and whose main clinical features are pancreatic insufficiency and chronic endobronchial infection. Although it was i...

journal_title：Clinical reviews in allergy & immunology

authors： Voter KZ,Ren CL

更新日期：2008-12-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a chronic, relapsing, systemic necrotizing vasculitis with typical pathologic findings of granulomatous inflammation and pauci-immune vasculitis. Untreated, the condition has a very high mortality, and contemporary treatment strategies carry a high risk of treatment-related morbidity. ...

journal_title：Clinical reviews in allergy & immunology

authors： Hinze CH,Colbert RA

更新日期：2008-06-01 00:00:00

abstract：:With the implementation of vaccination programs and the use of antibiotics, developed countries have seen a decline in infection-related pediatric bronchiectasis. However, significant morbidity from bronchiectasis is still seen and both infectious and noninfectious causes of bronchiectasis in the pediatric population ...

journal_title：Clinical reviews in allergy & immunology

authors： Boren EJ,Teuber SS,Gershwin ME

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65...

journal_title：Clinical reviews in allergy & immunology

authors： Poulsom H,Charles PJ

更新日期：2008-02-01 00:00:00

abstract：:Available data on small numbers of patients with refractory and/or relapsing Wegener's granulomatosis support very good overall outcomes with rituximab, an anti-CD20 biotherapy targeting B cells, in combination with ongoing immunosuppressants, apparently independently of antineutrophil cytoplasm antibody (ANCA) status...

journal_title：Clinical reviews in allergy & immunology

authors： Aouba A,Pagnoux C,Bienvenu B,Mahr A,Guillevin L

更新日期：2008-02-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) conceptually may be divided into three evolutionary stages: allostimulation, effector cell homing to specific tissues, and cellular targeting and injury. Surprisingly, little is known regarding the targeting stage of GVHD. Recently, we have learned that epithelial target cell inj...

journal_title：Clinical reviews in allergy & immunology

authors： Murphy GF

更新日期：2007-10-01 00:00:00

abstract：:Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far from being settled, recent studies have suggested a crucial role for B cells in its pathophysiology. Early investigations have focused on the ability of B cells to produce autoantibodies, and new studies have enlarged the ran...

journal_title：Clinical reviews in allergy & immunology

authors： Youinou P,Devauchelle V,Hutin P,Le Berre R,Saraux A,Pers JO

更新日期：2007-06-01 00:00:00

abstract：:The heart is a target organ in antiphospholipid syndrome (APS). Endocardial disease, intracardiac thrombosis, myocardial involvement including coronary heart disease and microvascular thrombosis, as well as pulmonary hypertension have all been described in APS patients. Valvular involvement is the most common manifest...

journal_title：Clinical reviews in allergy & immunology

authors： Amigo MC

更新日期：2007-04-01 00:00:00